1gio
From Proteopedia
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'''NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES''' | '''NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES''' | ||
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[[Category: Lequin, O.]] | [[Category: Lequin, O.]] | ||
[[Category: Spik, G.]] | [[Category: Spik, G.]] | ||
| - | [[Category: | + | [[Category: Endoribonuclease]] |
| - | [[Category: | + | [[Category: Hydrolase angiogenesis]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:37:14 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:37, 2 May 2008
NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES
Overview
The three-dimensional structure of bovine angiogenin has been determined using two- and three-dimensional proton NMR spectroscopy. The solution structure is very close to that recently determined by X-ray diffraction analysis. This structure appears well defined, even if five loops and one helix exhibit greater flexibility. Analysis of the active site geometry confirms the position of the Glu-118 residue which obstructs the pyrimidine binding site. There is no experimental evidence of an unobstructed conformation of angiogenin in solution. In addition, it appears that the Glu-118 and Ser-119 residues and the cell receptor binding loop may play an important role in the differences of C-terminal fragment organization and ribonucleolytic activity observed between angiogenins and ribonuclease A.
About this Structure
1GIO is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
Solution structure of bovine angiogenin by 1H nuclear magnetic resonance spectroscopy., Lequin O, Albaret C, Bontems F, Spik G, Lallemand JY, Biochemistry. 1996 Jul 9;35(27):8870-80. PMID:8688423 Page seeded by OCA on Fri May 2 17:37:14 2008
