1ugv

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<StructureSection load='1ugv' size='340' side='right'caption='[[1ugv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1ugv' size='340' side='right'caption='[[1ugv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ugv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1UGV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ugv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UGV FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA hg04539 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA hg04539 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ugv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugv OCA], [http://pdbe.org/1ugv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ugv RCSB], [http://www.ebi.ac.uk/pdbsum/1ugv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugv ProSAT], [http://www.topsan.org/Proteins/RSGI/1ugv TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ugv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugv OCA], [https://pdbe.org/1ugv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ugv RCSB], [https://www.ebi.ac.uk/pdbsum/1ugv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugv ProSAT], [https://www.topsan.org/Proteins/RSGI/1ugv TOPSAN]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[http://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
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[[https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[https://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] GTPase-activating protein for RHOA and CDC42.
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[[https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] GTPase-activating protein for RHOA and CDC42.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 06:45, 2 March 2022

Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)

PDB ID 1ugv

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