1uhp

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<StructureSection load='1uhp' size='340' side='right'caption='[[1uhp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1uhp' size='340' side='right'caption='[[1uhp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1uhp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1UHP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1uhp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UHP FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA1095 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA1095 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1uhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhp OCA], [http://pdbe.org/1uhp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uhp RCSB], [http://www.ebi.ac.uk/pdbsum/1uhp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uhp ProSAT], [http://www.topsan.org/Proteins/RSGI/1uhp TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhp OCA], [https://pdbe.org/1uhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uhp RCSB], [https://www.ebi.ac.uk/pdbsum/1uhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uhp ProSAT], [https://www.topsan.org/Proteins/RSGI/1uhp TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PZRN3_HUMAN PZRN3_HUMAN]] E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation (By similarity).
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[[https://www.uniprot.org/uniprot/PZRN3_HUMAN PZRN3_HUMAN]] E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 06:45, 2 March 2022

Solution structure of RSGI RUH-005, a PDZ domain in human cDNA, KIAA1095

PDB ID 1uhp

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