1wj1

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<StructureSection load='1wj1' size='340' side='right'caption='[[1wj1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1wj1' size='340' side='right'caption='[[1wj1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wj1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJ1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WJ1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wj1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WJ1 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 1200002O22 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 1200002O22 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wj1 OCA], [http://pdbe.org/1wj1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wj1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wj1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wj1 ProSAT], [http://www.topsan.org/Proteins/RSGI/1wj1 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wj1 OCA], [https://pdbe.org/1wj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wj1 RCSB], [https://www.ebi.ac.uk/pdbsum/1wj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wj1 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wj1 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NUMB_MOUSE NUMB_MOUSE]] Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.<ref>PMID:10841580</ref> <ref>PMID:12410312</ref> <ref>PMID:15273690</ref> <ref>PMID:17174898</ref>
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[[https://www.uniprot.org/uniprot/NUMB_MOUSE NUMB_MOUSE]] Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.<ref>PMID:10841580</ref> <ref>PMID:12410312</ref> <ref>PMID:15273690</ref> <ref>PMID:17174898</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 06:56, 2 March 2022

Solution structure of phosphotyrosine interaction domain of mouse Numb protein

PDB ID 1wj1

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