1wmv

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<StructureSection load='1wmv' size='340' side='right'caption='[[1wmv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1wmv' size='340' side='right'caption='[[1wmv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://pdbe.org/1wmv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [https://pdbe.org/1wmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [https://www.ebi.ac.uk/pdbsum/1wmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmv ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[http://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>
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[[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[https://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref> <ref>PMID:15548692</ref> <ref>PMID:15070730</ref> <ref>PMID:16061658</ref> <ref>PMID:16219768</ref> <ref>PMID:19366691</ref> <ref>PMID:19465938</ref>
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[[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref> <ref>PMID:15548692</ref> <ref>PMID:15070730</ref> <ref>PMID:16061658</ref> <ref>PMID:16219768</ref> <ref>PMID:19366691</ref> <ref>PMID:19465938</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 06:58, 2 March 2022

Solution structure of the second WW domain of WWOX

PDB ID 1wmv

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