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1x57
From Proteopedia
(Difference between revisions)
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<StructureSection load='1x57' size='340' side='right'caption='[[1x57]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='1x57' size='340' side='right'caption='[[1x57]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1x57]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1x57]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X57 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EDF-1 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EDF-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x57 OCA], [https://pdbe.org/1x57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x57 RCSB], [https://www.ebi.ac.uk/pdbsum/1x57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x57 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x57 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/EDF1_HUMAN EDF1_HUMAN]] Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.<ref>PMID:9813014</ref> <ref>PMID:10567391</ref> <ref>PMID:12040021</ref> <ref>PMID:15112053</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 07:05, 2 March 2022
Solution structures of the HTH domain of human EDF-1 protein
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