1x61

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<StructureSection load='1x61' size='340' side='right'caption='[[1x61]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1x61' size='340' side='right'caption='[[1x61]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1x61]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X61 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1X61 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1x61]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X61 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRIP6, OIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRIP6, OIP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1x61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x61 OCA], [http://pdbe.org/1x61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x61 RCSB], [http://www.ebi.ac.uk/pdbsum/1x61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1x61 ProSAT], [http://www.topsan.org/Proteins/RSGI/1x61 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x61 OCA], [https://pdbe.org/1x61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x61 RCSB], [https://www.ebi.ac.uk/pdbsum/1x61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x61 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x61 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRIP6_HUMAN TRIP6_HUMAN]] Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.<ref>PMID:15489293</ref> <ref>PMID:14688263</ref> <ref>PMID:16624523</ref> <ref>PMID:19017743</ref>
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[[https://www.uniprot.org/uniprot/TRIP6_HUMAN TRIP6_HUMAN]] Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.<ref>PMID:15489293</ref> <ref>PMID:14688263</ref> <ref>PMID:16624523</ref> <ref>PMID:19017743</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 07:06, 2 March 2022

Solution structure of the first LIM domain of thyroid receptor interacting protein 6 (TRIP6)

PDB ID 1x61

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