2omj
From Proteopedia
(Difference between revisions)
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<StructureSection load='2omj' size='340' side='right'caption='[[2omj]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2omj' size='340' side='right'caption='[[2omj]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2omj]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2omj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OMJ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2omj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2omj OCA], [https://pdbe.org/2omj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2omj RCSB], [https://www.ebi.ac.uk/pdbsum/2omj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2omj ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN]] Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN]] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.<ref>PMID:11094164</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 07:52, 2 March 2022
solution structure of LARG PDZ domain
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