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3fvo
From Proteopedia
(Difference between revisions)
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<StructureSection load='3fvo' size='340' side='right'caption='[[3fvo]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='3fvo' size='340' side='right'caption='[[3fvo]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FVO FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zns|2zns]], [[2znt|2znt]], [[2znu|2znu]], [[3fuz|3fuz]], [[3fv1|3fv1]], [[3fv2|3fv2]], [[3fvg|3fvg]], [[3fvk|3fvk]], [[3fvn|3fvn]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zns|2zns]], [[2znt|2znt]], [[2znu|2znu]], [[3fuz|3fuz]], [[3fv1|3fv1]], [[3fv2|3fv2]], [[3fvg|3fvg]], [[3fvk|3fvk]], [[3fvn|3fvn]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvo OCA], [https://pdbe.org/3fvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fvo RCSB], [https://www.ebi.ac.uk/pdbsum/3fvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvo ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/GRIK1_HUMAN GRIK1_HUMAN]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 08:12, 2 March 2022
Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-epi-neodysiherbaine A in space group P1
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