3gbw

<StructureSection load='3gbw' size='340' side='right' caption='[[3gbw]], [[Resolution|resolution]] 1.32&Aring;' scene=''>

<table><tr><td colspan='2'>[[3gbw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBW FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbw OCA], [http://pdbe.org/3gbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbw RCSB], [http://www.ebi.ac.uk/pdbsum/3gbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbw ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/3gbw TOPSAN]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/MYCB2_MOUSE MYCB2_MOUSE]] Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.<ref>PMID:14729956</ref>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbw_consurf.spt"</scriptWhenChecked>

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== Publication Abstract from PubMed ==

PHR [PAM (protein associated with Myc)-HIW (Highwire)-RPM-1 (regulator of presynaptic morphology 1)] proteins are conserved, large multi-domain E3 ubiquitin ligases with modular architecture. PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptically regulate endocytosis of glutamate receptors. Dysfunction of neuronal ubiquitin-mediated proteasomal degradation is implicated in various neurodegenerative diseases. PHR proteins are characterized by the presence of two PHR domains near the N-terminus, which are essential for proper localization and function. Structures of both the first and second PHR domains of Mus musculus (mouse) Phr1 (MYC binding protein 2, Mycbp2) have been determined, revealing a novel beta sandwich fold composed of 11 antiparallel beta-strands. Conserved loops decorate the apical side of the first PHR domain (MmPHR1), yielding a distinct conserved surface feature. The surface of the second PHR domain (MmPHR2), in contrast, lacks significant conservation. Importantly, the structure of MmPHR1 provides insights into a loss-of-function mutation, Gly1092--&gt;Glu, observed in the Caenorhabditis elegans ortholog RPM-1.

 

== References ==

[[Category: Lk3 transgenic mice]]

[[Category: Atwell, S]]

[[Category: Bain, K T]]

[[Category: Burley, S K]]

[[Category: Klemke, R L]]

[[Category: Miller, S A]]

[[Category: Structural genomic]]

[[Category: Ozyurt, S A]]

[[Category: Rutter, M E]]

[[Category: Sampathkumar, P]]

[[Category: Sauder, J M]]

[[Category: Tarun, G]]

[[Category: Wasserman, S R]]

[[Category: Zinc-finger]]