SAICAR synthetase

From Proteopedia

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Current revision (11:18, 9 March 2022) (edit) (undo)
 
Line 18: Line 18:
**[[1a48]] – ySAI - yeast<br />
**[[1a48]] – ySAI - yeast<br />
-
**[[3r9r]] – SAI – ''Mycobacterium abscessus'' <br />
+
**[[3r9r]], [[6yvq]] – MaSAI – ''Mycobacterium abscessus'' <br />
**[[3kre]] – SAI – ''Ehrlichia chaffeensis'' <br />
**[[3kre]] – SAI – ''Ehrlichia chaffeensis'' <br />
**[[1kut]] – SAI – ''Thermotoga maritima''<br />
**[[1kut]] – SAI – ''Thermotoga maritima''<br />
Line 37: Line 37:
**[[2gqr]] – EcSAI + ADP – ''Escherichia coli''<br />
**[[2gqr]] – EcSAI + ADP – ''Escherichia coli''<br />
**[[2gqs]] – EcSAI + ADP + AICAR <br />
**[[2gqs]] – EcSAI + ADP + AICAR <br />
 +
**[[6yy6]], [[6yy7]], [[6yy8]], [[6yy9]], [[6yya]], [[6yyb]], [[6yyc]], [[6yyd]], [[6z0q]], [[6z0r]] – MaSAI + inhibitor<br />
 +
**[[6yx3]] – MaSAI + ATP <br />
*SAICAR synthetase type-1
*SAICAR synthetase type-1

Current revision

SAICAR synthetase complex with aminoimidazole-ribonucleotide, ADP, TRIS, aspartate, acetate, Mg+2 and Cl- ions (PDB code 4fe2)

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3D structures of SAICAR synthetase

Updated on 09-March-2022

References

  1. Manjunath K, Jeyakanthan J, Sekar K. Catalytic pathway, substrate binding and stability in SAICAR synthetase: A structure and molecular dynamics study. J Struct Biol. 2015 Jul;191(1):22-31. doi: 10.1016/j.jsb.2015.06.006. Epub 2015, Jun 10. PMID:26072057 doi:http://dx.doi.org/10.1016/j.jsb.2015.06.006
  2. Wolf NM, Abad-Zapatero C, Johnson ME, Fung LW. Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg(2+), AIR and Asp. Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):841-50. doi:, 10.1107/S139900471303366X. Epub 2014 Feb 22. PMID:24598753 doi:http://dx.doi.org/10.1107/S139900471303366X

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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