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Selenocysteine synthase

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Current revision (08:31, 15 March 2022) (edit) (undo)
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[4zdl]] – hSecS (mutant) - human<br />
 +
[[3hl2]] - hSecS + tRNASec <br />
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[[4zdo]], [[4zdp]] – hSecS (mutant) + tRNASec<br />
 +
[[7l1t]] – hSecS + pyridoxine derivative <br />
[[3bc8]], [[3bca]] - mSecS elastase-resistant fragment - mouse
[[3bc8]], [[3bca]] - mSecS elastase-resistant fragment - mouse
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[[2z67]] - SecS - ''Methanococcus maripaludis''
[[2z67]] - SecS - ''Methanococcus maripaludis''
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[[3hl2]] - hSecS + tRNASec + PLP - human<br />
 
-
[[4zdl]] – hSecS (mutant) <br />
 
-
[[4zdo]], [[4zdp]] – hSecS (mutant) + tRNASec<br />
 
[[3w1i]] – AaSecS + pyridine derivative – ''Aquifex aeolicus''<br />
[[3w1i]] – AaSecS + pyridine derivative – ''Aquifex aeolicus''<br />
[[3wcn]] – AaSecS (mutant) <br />
[[3wcn]] – AaSecS (mutant) <br />

Current revision

Human selenocysteine synthase containing phosphoserine complex with tRNASec, monothiophosphate, deoxypyridoxine phosphate (PDB entry 3hl2)

Drag the structure with the mouse to rotate

3D Structures of selenocysteine synthase

Updated on 15-March-2022

4zdl – hSecS (mutant) - human
3hl2 - hSecS + tRNASec
4zdo, 4zdp – hSecS (mutant) + tRNASec
7l1t – hSecS + pyridoxine derivative
3bc8, 3bca - mSecS elastase-resistant fragment - mouse

3bcb - mSecS elastase-resistant fragment + phosphate

2z67 - SecS - Methanococcus maripaludis

3w1i – AaSecS + pyridine derivative – Aquifex aeolicus
3wcn – AaSecS (mutant)
3w1h, 3wco – AaSecS (mutant) + pyridine derivative
3w1j – AaSecS + pyridine derivative
3w1k – AaSecS (mutant) + pyridine derivative + tRNASec

References

  1. ↑ Forchhammer K, Boesmiller K, Bock A. The function of selenocysteine synthase and SELB in the synthesis and incorporation of selenocysteine. Biochimie. 1991 Dec;73(12):1481-6. PMID:1839607
  2. ↑ Schweizer U, Dehina N, Schomburg L. Disorders of selenium metabolism and selenoprotein function. Curr Opin Pediatr. 2011 Aug;23(4):429-35. doi: 10.1097/MOP.0b013e32834877da. PMID:21670677 doi:http://dx.doi.org/10.1097/MOP.0b013e32834877da
  3. ↑ Palioura S, Sherrer RL, Steitz TA, Soll D, Simonovic M. The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation. Science. 2009 Jul 17;325(5938):321-5. PMID:19608919 doi:325/5938/321

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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