Semaphorin

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== Structural insights ==
== Structural insights ==
SEMA interacts with plexin C1 via 3 regions: <scene name='46/466531/Cv/5'>SEMA extrusion helix</scene>, <scene name='46/466531/Cv/6'>loop4c-4d</scene> and <scene name='46/466531/Cv/7'>blade 3</scene><ref>PMID:20727575</ref>. Water molecules are shown as red spheres.
SEMA interacts with plexin C1 via 3 regions: <scene name='46/466531/Cv/5'>SEMA extrusion helix</scene>, <scene name='46/466531/Cv/6'>loop4c-4d</scene> and <scene name='46/466531/Cv/7'>blade 3</scene><ref>PMID:20727575</ref>. Water molecules are shown as red spheres.
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</StructureSection>
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==3D structures of semaphorin==
==3D structures of semaphorin==
[[Semaphorin 3D structures]]
[[Semaphorin 3D structures]]
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{{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Semaphorin 1A
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**[[6qp9]] – DmSEMA 1A domain 1-2 – ''Drosophila melanogaster''<br />
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*Semaphorin 1B
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**[[6fkk]] – DmSEMA 1B extracellular domains 37-602<br />
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**[[6fkm]], [[6fkn]] – DmSEMA 1B extracellular domains + plexin A<br />
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*Semaphorin 2A
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**[[6qp7]] – DmSEMA 2A <br />
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*Semaphorin 2B
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**[[6qp8]] – DmSEMA 2B <br />
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*Semaphorin 3A
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**[[1q47]], [[4gz8]] – mSEMA 3A – mouse<br />
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**[[4gza]] – mSEMA 3A + plexin A2 + neuropilin 1<br />
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**[[7m0r]] – mSEMA 3A + plexin A4 + neuropilin 1 – Cryo EM<br />
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*Semaphorin 4
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**[[1olz]] – hSEMA 4D extracellular domain – human
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**[[3ol2]] - hSEMA 4D extracellular domain + plexin-B1
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*Semaphorin 6A
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**[[6wts]] – hSEMA 6A + cytotoxin L <br />
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**[[3afc]], [[3okw]] - mSEMA 6A extracellular domain
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**[[3al8]], [[3oky]] - mSEMA 6A + plexin-A2
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*Semaphorin 7
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**[[3nvn]], [[3nvq]], [[3nvx]] – hSEMA 7A + plexin-C1
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}}
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== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:46, 15 March 2022

Glycosylated human semaphorin 7A (deeppink) complex with plexin-C1 (cyan) and Ca+2 ion (green), 3nvn

Drag the structure with the mouse to rotate

References

  1. ↑ Nakamura F, Kalb RG, Strittmatter SM. Molecular basis of semaphorin-mediated axon guidance. J Neurobiol. 2000 Aug;44(2):219-29. PMID:10934324
  2. ↑ Behar O, Golden JA, Mashimo H, Schoen FJ, Fishman MC. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature. 1996 Oct 10;383(6600):525-8. PMID:8849723 doi:http://dx.doi.org/10.1038/383525a0
  3. ↑ Yang YH, Buhamrah A, Schneider A, Lin YL, Zhou H, Bugshan A, Basile JR. Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer. PLoS One. 2016 Feb 24;11(2):e0150151. doi: 10.1371/journal.pone.0150151., eCollection 2016. PMID:26910109 doi:http://dx.doi.org/10.1371/journal.pone.0150151
  4. ↑ Pasterkamp RJ, Peschon JJ, Spriggs MK, Kolodkin AL. Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature. 2003 Jul 24;424(6947):398-405. PMID:12879062 doi:http://dx.doi.org/10.1038/nature01790
  5. ↑ Pasterkamp RJ, Giger RJ. Semaphorin function in neural plasticity and disease. Curr Opin Neurobiol. 2009 Jun;19(3):263-74. doi: 10.1016/j.conb.2009.06.001. Epub, 2009 Jun 21. PMID:19541473 doi:http://dx.doi.org/10.1016/j.conb.2009.06.001
  6. ↑ Vadasz Z, Toubi E. Semaphorin 3A - a marker for disease activity and a potential putative disease-modifying treatment in systemic lupus erythematosus. Lupus. 2012 Oct;21(12):1266-70. Epub 2012 Aug 8. PMID:22875653 doi:http://dx.doi.org/10.1177/0961203312456753
  7. ↑ Liu H, Juo ZS, Shim AH, Focia PJ, Chen X, Garcia KC, He X. Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. Cell. 2010 Sep 3;142(5):749-61. Epub 2010 Aug 19. PMID:20727575 doi:10.1016/j.cell.2010.07.040

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Michal Harel, Alexander Berchansky

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