1glo

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[[Image:1glo.jpg|left|200px]]
[[Image:1glo.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1glo |SIZE=350|CAPTION= <scene name='initialview01'>1glo</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1glo", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CAT:Active+Site+Residues+In+Native+Enzyme'>CAT</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1glo| PDB=1glo | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1glo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glo OCA], [http://www.ebi.ac.uk/pdbsum/1glo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1glo RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S'''
'''CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S'''
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[[Category: Williams, D H.]]
[[Category: Williams, D H.]]
[[Category: Wright, L M.]]
[[Category: Wright, L M.]]
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[[Category: cathepsin s]]
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[[Category: Cathepsin s]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: proteinase]]
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[[Category: Proteinase]]
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[[Category: thiol protea]]
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[[Category: Thiol protea]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:43:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:46:41 2008''
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Revision as of 14:43, 2 May 2008

Image:1glo.jpg

Template:STRUCTURE 1glo

CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S


Overview

Cathepsin S (EC 3.4.22.27), a cysteine proteinase of the papain superfamily, plays a critical role in the generation of a major histocompatibility complex (MHC) class II restricted T-cell response by antigen-presenting cells. Therefore, selective inhibition of this enzyme may be useful in modulating class II restricted T-cell responses in immune-related disorders such as rheumatoid arthritis, multiple sclerosis and extrinsic asthma. The three-dimensional structure at 2.2 A resolution of the active-site Cys25-->Ser mutant presented here in an unliganded state provides further insight useful for the design of selective enzyme inhibitors.

About this Structure

1GLO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a Cys25-->Ser mutant of human cathepsin S., Turkenburg JP, Lamers MB, Brzozowski AM, Wright LM, Hubbard RE, Sturt SL, Williams DH, Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):451-5. Epub 2002, Feb 21. PMID:11856830 Page seeded by OCA on Fri May 2 17:43:48 2008

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