7o6x
From Proteopedia
(Difference between revisions)
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==Tankyrase 2 in complex with an inhibitor (OM-153)== | ==Tankyrase 2 in complex with an inhibitor (OM-153)== | ||
| - | <StructureSection load='7o6x' size='340' side='right'caption='[[7o6x]]' scene=''> | + | <StructureSection load='7o6x' size='340' side='right'caption='[[7o6x]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O6X FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7o6x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O6X FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o6x OCA], [https://pdbe.org/7o6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o6x RCSB], [https://www.ebi.ac.uk/pdbsum/7o6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o6x ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=V4Q:N-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]quinoxaline-5-carboxamide'>V4Q</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o6x OCA], [https://pdbe.org/7o6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o6x RCSB], [https://www.ebi.ac.uk/pdbsum/7o6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o6x ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Lehtio L]] | + | [[Category: Lehtio, L]] |
| - | [[Category: Sowa | + | [[Category: Sowa, S T]] |
| + | [[Category: Complex]] | ||
| + | [[Category: Enzyme]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Poly-adp-ribosylation]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:18, 16 March 2022
Tankyrase 2 in complex with an inhibitor (OM-153)
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