7rw4
From Proteopedia
(Difference between revisions)
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==Crystal structure of junctophilin-1== | ==Crystal structure of junctophilin-1== | ||
| - | <StructureSection load='7rw4' size='340' side='right'caption='[[7rw4]]' scene=''> | + | <StructureSection load='7rw4' size='340' side='right'caption='[[7rw4]], [[Resolution|resolution]] 1.31Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RW4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rw4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RW4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rw4 OCA], [https://pdbe.org/7rw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rw4 RCSB], [https://www.ebi.ac.uk/pdbsum/7rw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rw4 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rw4 OCA], [https://pdbe.org/7rw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rw4 RCSB], [https://www.ebi.ac.uk/pdbsum/7rw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rw4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/JPH1_HUMAN JPH1_HUMAN]] Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | SignificanceIon channels have evolved the ability to communicate with one another, either through protein-protein interactions, or indirectly via intermediate diffusible messenger molecules. In special cases, the channels are part of different membranes. In muscle tissue, the T-tubule membrane is in proximity to the sarcoplasmic reticulum, allowing communication between L-type calcium channels and ryanodine receptors. This process is critical for excitation-contraction coupling and requires auxiliary proteins like junctophilin (JPH). JPHs are targets for disease-associated mutations, most notably hypertrophic cardiomyopathy mutations in the JPH2 isoform. Here we provide high-resolution snapshots of JPH, both alone and in complex with a calcium channel peptide, and show how this interaction is targeted by cardiomyopathy mutations. | ||
| + | |||
| + | Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations.,Yang ZF, Panwar P, McFarlane CR, Tuinte WE, Campiglio M, Van Petegem F Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2120416119. doi:, 10.1073/pnas.2120416119. Epub 2022 Mar 1. PMID:35238659<ref>PMID:35238659</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7rw4" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Panwar P]] | + | [[Category: Panwar, P]] |
| - | [[Category: | + | [[Category: Petegem, F Van]] |
| - | [[Category: Yang Z]] | + | [[Category: Yang, Z]] |
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: Muscle]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 07:23, 16 March 2022
Crystal structure of junctophilin-1
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