7vdy
From Proteopedia
(Difference between revisions)
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==Crystal structure of O-ureidoserine racemase== | ==Crystal structure of O-ureidoserine racemase== | ||
| - | <StructureSection load='7vdy' size='340' side='right'caption='[[7vdy]]' scene=''> | + | <StructureSection load='7vdy' size='340' side='right'caption='[[7vdy]], [[Resolution|resolution]] 2.12Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VDY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VDY FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7vdy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VDY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VDY FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vdy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vdy OCA], [https://pdbe.org/7vdy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vdy RCSB], [https://www.ebi.ac.uk/pdbsum/7vdy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vdy ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/O-ureido-serine_racemase O-ureido-serine racemase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.19 5.1.1.19] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vdy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vdy OCA], [https://pdbe.org/7vdy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vdy RCSB], [https://www.ebi.ac.uk/pdbsum/7vdy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vdy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/DCSC_STRLA DCSC_STRLA]] Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the stereoinversion of O-ureido-L-serine to O-ureido-D-serine.<ref>PMID:20086163</ref> <ref>PMID:22307920</ref> <ref>PMID:23529730</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The O-ureidoserine racemase (DcsC) is an enzyme found from the biosynthetic gene cluster of antitubercular agent d-cycloserine. Although DcsC is homologous to diaminopimelate epimerase (DapF) that catalyzes the interconversion between ll- and dl-diaminopimelic acid, it specifically catalyzes the interconversion between O-ureido-l-serine and its enantiomer. Here we determined the crystal structure of DcsC at a resolution of 2.12 A, implicating that the catalytic mechanism of DcsC shares similarity with that of DapF. Comparing the structure of the active center of DcsC to that of DapF, Thr72, Thr198, and Tyr219 of DcsC are likely to be involved in the substrate specificity. | ||
| + | |||
| + | Crystal structure of O-ureidoserine racemase found in the d-cycloserine biosynthetic pathway.,Oda K, Sakaguchi T, Matoba Y Proteins. 2022 Apr;90(4):912-918. doi: 10.1002/prot.26290. Epub 2021 Dec 17. PMID:34877716<ref>PMID:34877716</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7vdy" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Matoba Y]] | + | [[Category: O-ureido-serine racemase]] |
| - | [[Category: Oda K]] | + | [[Category: Matoba, Y]] |
| + | [[Category: Oda, K]] | ||
| + | [[Category: Isomerase]] | ||
| + | [[Category: Racemase]] | ||
Revision as of 07:25, 16 March 2022
Crystal structure of O-ureidoserine racemase
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