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3gp8
From Proteopedia
(Difference between revisions)
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==Crystal structure of the binary complex of RecD2 with DNA== | ==Crystal structure of the binary complex of RecD2 with DNA== | ||
| - | <StructureSection load='3gp8' size='340' side='right' caption='[[3gp8]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3gp8' size='340' side='right'caption='[[3gp8]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3gp8]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3gp8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deira Deira]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GP8 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gpl|3gpl]], [[3e1s|3e1s]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gpl|3gpl]], [[3e1s|3e1s]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DR_1902, recD ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DR_1902, recD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243230 DEIRA])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gp8 OCA], [https://pdbe.org/3gp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gp8 RCSB], [https://www.ebi.ac.uk/pdbsum/3gp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gp8 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/RECDL_DEIRA RECDL_DEIRA]] DNA-dependent ATPase (ssDNA better than dsDNA) and ATP-dependent 5'-3' DNA helicase. Appears to move along DNA in single base steps, powered by hydrolysis of 1 molecule of ATP. Has low processivity; short (20 bp) substrates with 5'-overhangs or forked ends are the best substrates, is much less efficient on 52 or 76 bp substrates with 5'- overhangs. The presence of single-stranded DNA-binding protein (SSB) increases unwinding 4-5 fold. Has no activity on blunt DNA or DNA with 3'-overhangs. Requires at least 10 bases of 5'-ssDNA for helicase activity.<ref>PMID:15466873</ref> <ref>PMID:19490894</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Exonuclease|Exonuclease]] | + | *[[Exonuclease 3D structures|Exonuclease 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Deira]] | [[Category: Deira]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Cook, N]] | [[Category: Cook, N]] | ||
[[Category: Saikrishnan, K]] | [[Category: Saikrishnan, K]] | ||
Revision as of 07:51, 16 March 2022
Crystal structure of the binary complex of RecD2 with DNA
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