3h0j

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==Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 2==
==Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 2==
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<StructureSection load='3h0j' size='340' side='right' caption='[[3h0j]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='3h0j' size='340' side='right'caption='[[3h0j]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3h0j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H0J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3h0j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H0J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B36:6-{[1-(ANTHRACEN-9-YLCARBONYL)PIPERIDIN-4-YL]METHYL}-2-METHYLQUINOLINE'>B36</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B36:6-{[1-(ANTHRACEN-9-YLCARBONYL)PIPERIDIN-4-YL]METHYL}-2-METHYLQUINOLINE'>B36</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3h0q|3h0q]], [[3h0s|3h0s]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3h0q|3h0q]], [[3h0s|3h0s]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FAS3, ACC1, YNR016C, N3175 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FAS3, ACC1, YNR016C, N3175 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h0j OCA], [http://pdbe.org/3h0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h0j RCSB], [http://www.ebi.ac.uk/pdbsum/3h0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3h0j ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h0j OCA], [https://pdbe.org/3h0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h0j RCSB], [https://www.ebi.ac.uk/pdbsum/3h0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h0j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACAC_YEAST ACAC_YEAST]] Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.<ref>PMID:6108218</ref> <ref>PMID:6103540</ref> <ref>PMID:8943372</ref> <ref>PMID:10757783</ref> <ref>PMID:12730220</ref>
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[[https://www.uniprot.org/uniprot/ACAC_YEAST ACAC_YEAST]] Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.<ref>PMID:6108218</ref> <ref>PMID:6103540</ref> <ref>PMID:8943372</ref> <ref>PMID:10757783</ref> <ref>PMID:12730220</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Acetyl-CoA carboxylase|Acetyl-CoA carboxylase]]
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*[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Atcc 18824]]
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[[Category: Large Structures]]
[[Category: Tong, L]]
[[Category: Tong, L]]
[[Category: Zhang, H]]
[[Category: Zhang, H]]

Revision as of 07:59, 16 March 2022

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 2

PDB ID 3h0j

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