1gnh

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[[Image:1gnh.gif|left|200px]]
[[Image:1gnh.gif|left|200px]]
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{{Structure
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|PDB= 1gnh |SIZE=350|CAPTION= <scene name='initialview01'>1gnh</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1gnh", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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{{STRUCTURE_1gnh| PDB=1gnh | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnh OCA], [http://www.ebi.ac.uk/pdbsum/1gnh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gnh RCSB]</span>
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'''HUMAN C-REACTIVE PROTEIN'''
'''HUMAN C-REACTIVE PROTEIN'''
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[[Category: Turnell, W G.]]
[[Category: Turnell, W G.]]
[[Category: Volanakis, J E.]]
[[Category: Volanakis, J E.]]
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[[Category: acute-phase protein]]
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[[Category: Acute-phase protein]]
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[[Category: acute-phase reactant]]
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[[Category: Acute-phase reactant]]
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[[Category: pentraxin]]
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[[Category: Pentraxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:47:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:47:43 2008''
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Revision as of 14:47, 2 May 2008

Image:1gnh.gif


PDB ID 1gnh

Drag the structure with the mouse to rotate
1gnh, resolution 3.00Å ()
Ligands:
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



HUMAN C-REACTIVE PROTEIN


Overview

The structure of the classical acute phase reactant human C-reactive protein provides evidence that phosphocholine binding is mediated through calcium and a hydrophobic pocket centred on Phe 66. The residue Glu 81 is suitably positioned to interact with the choline group. A cleft on the pentameric face opposite to that containing the calcium site may have an important functional role. The structure provides insights into the molecular mechanisms by which this highly conserved plasma protein, for which no polymorphism or deficiency state is known, may exert its biological role.

About this Structure

1GNH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three dimensional structure of human C-reactive protein., Shrive AK, Cheetham GM, Holden D, Myles DA, Turnell WG, Volanakis JE, Pepys MB, Bloomer AC, Greenhough TJ, Nat Struct Biol. 1996 Apr;3(4):346-54. PMID:8599761 Page seeded by OCA on Fri May 2 17:47:08 2008

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