3ha5
From Proteopedia
(Difference between revisions)
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==Crystal structure of HMA (MMAA4) from mycobacterium tuberculosis complexed with sinefungin== | ==Crystal structure of HMA (MMAA4) from mycobacterium tuberculosis complexed with sinefungin== | ||
| - | <StructureSection load='3ha5' size='340' side='right' caption='[[3ha5]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='3ha5' size='340' side='right'caption='[[3ha5]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ha5]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ha5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HA5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2fk7|2fk7]], [[2fk8|2fk8]], [[3ha3|3ha3]], [[3ha7|3ha7]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fk7|2fk7]], [[2fk8|2fk8]], [[3ha3|3ha3]], [[3ha7|3ha7]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mmaA4, MMAA4 (RV0642C), Rv0642c ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mmaA4, MMAA4 (RV0642C), Rv0642c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ha5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ha5 OCA], [https://pdbe.org/3ha5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ha5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ha5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ha5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MMAA4_MYCTU MMAA4_MYCTU]] Involved in the biosynthesis of hydroxymycolate, a common precursor of oxygenated mycolic acids (methoxy-mycolate and keto-mycolate). Probably transfers a methyl group from the S-adenosylmethionine (SAM) cofactor and, subsequently or simultaneously, a water molecule onto the double bound of ethylene substrates, leading to the formation of the hydroxylated product at the distal position. Involved in the activation of the antitubercular drug thiacetazone (TAC).<ref>PMID:10844652</ref> <ref>PMID:12473649</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Myctu]] | [[Category: Myctu]] | ||
[[Category: Boissier, F]] | [[Category: Boissier, F]] | ||
Revision as of 08:07, 16 March 2022
Crystal structure of HMA (MMAA4) from mycobacterium tuberculosis complexed with sinefungin
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