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1e31
From Proteopedia
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(New page: 200px<br /> <applet load="1e31" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e31, resolution 2.71Å" /> '''SURVIVIN DIMER H. S...)
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Revision as of 14:32, 12 November 2007
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SURVIVIN DIMER H. SAPIENS
Overview
Survivin is a mitotic spindle-associated protein involved in linking, mitotic spindle function to activation of apoptosis in mammalian cells., The structure of the full-length human survivin has been determined by, X-ray crystallography to 2.7 A. Strikingly, the structure forms a very, unusual bow tie-shaped dimer. It does not dimerize through a C-terminal, coiled-coil, contrary to sequence analysis prediction. The C-terminal, helices contain hydrophobic clusters with the potential for, protein-protein interactions. The unusual shape and dimensions of survivin, suggest it serves an adaptor function through its alpha-helical, extensions.
About this Structure
1E31 is a Single protein structure of sequence from Homo sapiens with ZN and CO as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions., Chantalat L, Skoufias DA, Kleman JP, Jung B, Dideberg O, Margolis RL, Mol Cell. 2000 Jul;6(1):183-9. PMID:10949039
Page seeded by OCA on Mon Nov 12 16:39:11 2007
Categories: Homo sapiens | Single protein | Chantalat, L. | Dideberg, O. | Margolis, R. | Skoufias, D. | CO | ZN | Apotosis | Iap | Zinc finger
