1gor

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[[Image:1gor.gif|left|200px]]
[[Image:1gor.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1gor |SIZE=350|CAPTION= <scene name='initialview01'>1gor</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1gor", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ACI:Xyp+Binding+Site'>ACI</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene>, <scene name='pdbligand=XYS:XYLOPYRANOSE'>XYS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1gor| PDB=1gor | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gor OCA], [http://www.ebi.ac.uk/pdbsum/1gor PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gor RCSB]</span>
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}}
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'''THERMOSTABLE XYLANASE I FROM THERMOASCUS AURANTIACUS-XYLOBIOSE COMPLEX AT 100 K'''
'''THERMOSTABLE XYLANASE I FROM THERMOASCUS AURANTIACUS-XYLOBIOSE COMPLEX AT 100 K'''
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[[Category: Larsen, S.]]
[[Category: Larsen, S.]]
[[Category: Leggio, L Lo.]]
[[Category: Leggio, L Lo.]]
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[[Category: family 10]]
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[[Category: Family 10]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: plant cell wall degradation]]
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[[Category: Plant cell wall degradation]]
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[[Category: thermostable]]
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[[Category: Thermostable]]
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[[Category: xylanase]]
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[[Category: Xylanase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:50:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:48:19 2008''
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Revision as of 14:50, 2 May 2008

Image:1gor.gif

Template:STRUCTURE 1gor

THERMOSTABLE XYLANASE I FROM THERMOASCUS AURANTIACUS-XYLOBIOSE COMPLEX AT 100 K


Overview

The substrate specificity of Thermoascus aurantiacus xylanase 10A (TAX) has been investigated both biochemically and structurally. High resolution crystallographic analyses at 291 K and 100 K of TAX complexes with xylobiose show that the ligand is in its alpha anomeric conformation and provide a rationale for specificity on p-nitrophenyl glycosides at the -1 and -2 subsites. Trp 275, which is disordered in uncomplexed structures, is stabilised by its interaction with xylobiose. Two structural subsets in family 10 are identified, which differ by the presence or absence of a short helical stretch in the eighth betaalpha-loop of the TIM barrel, the loop bearing Trp 275. This structural difference is discussed in the context of Trp 275 mobility and xylanase function.

About this Structure

1GOR is a Single protein structure of sequence from Thermoascus aurantiacus. Full crystallographic information is available from OCA.

Reference

Substrate specificity and subsite mobility in T. aurantiacus xylanase 10A., Lo Leggio L, Kalogiannis S, Eckert K, Teixeira SC, Bhat MK, Andrei C, Pickersgill RW, Larsen S, FEBS Lett. 2001 Dec 7;509(2):303-8. PMID:11741607 Page seeded by OCA on Fri May 2 17:50:00 2008

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