7f6v
From Proteopedia
(Difference between revisions)
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==Cryo-EM structure of the human TACAN channel in a closed state== | ==Cryo-EM structure of the human TACAN channel in a closed state== | ||
| - | <StructureSection load='7f6v' size='340' side='right'caption='[[7f6v]]' scene=''> | + | <StructureSection load='7f6v' size='340' side='right'caption='[[7f6v]], [[Resolution|resolution]] 3.66Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F6V FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7f6v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F6V FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f6v OCA], [https://pdbe.org/7f6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f6v RCSB], [https://www.ebi.ac.uk/pdbsum/7f6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f6v ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f6v OCA], [https://pdbe.org/7f6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f6v RCSB], [https://www.ebi.ac.uk/pdbsum/7f6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f6v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/TACAN_HUMAN TACAN_HUMAN]] Ion channel involved in sensing mechanical pain. Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli (By similarity). May also be required for efficient adipogenesis (PubMed:26024229).[UniProtKB:Q8C1E7]<ref>PMID:26024229</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | TACAN is an ion channel-like protein that may be involved in sensing mechanical pain. Here, we present the cryo-electron microscopic structure of human TACAN (hTACAN). hTACAN forms a dimer in which each protomer consists of a transmembrane globular domain (TMD) containing six helices and an intracellular domain (ICD) containing two helices. Molecular dynamic simulations suggest that each protomer contains a putative ion conduction pore. A single-point mutation of the key residue Met207 greatly increases membrane pressure-activated currents. In addition, each hTACAN subunit binds one cholesterol molecule. Our data show the molecular assembly of hTACAN and suggest that wild-type hTACAN is in a closed state. | ||
| + | |||
| + | Cryo-EM structure of the human TACAN in a closed state.,Chen X, Wang Y, Li Y, Lu X, Chen J, Li M, Wen T, Liu N, Chang S, Zhang X, Yang X, Shen Y Cell Rep. 2022 Mar 1;38(9):110445. doi: 10.1016/j.celrep.2022.110445. PMID:35235791<ref>PMID:35235791</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7f6v" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Chen | + | [[Category: Chen, X Z]] |
| - | [[Category: Li Y]] | + | [[Category: Li, Y]] |
| - | [[Category: Shen | + | [[Category: Shen, Y Q]] |
| - | [[Category: Wang | + | [[Category: Wang, Y J]] |
| - | [[Category: Yang X]] | + | [[Category: Yang, X]] |
| + | [[Category: Dimer]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 11:54, 23 March 2022
Cryo-EM structure of the human TACAN channel in a closed state
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Categories: Large Structures | Chen, X Z | Li, Y | Shen, Y Q | Wang, Y J | Yang, X | Dimer | Membrane protein
