7raa
From Proteopedia
(Difference between revisions)
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==Designed StabIL-2 seq15== | ==Designed StabIL-2 seq15== | ||
| - | <StructureSection load='7raa' size='340' side='right'caption='[[7raa]]' scene=''> | + | <StructureSection load='7raa' size='340' side='right'caption='[[7raa]], [[Resolution|resolution]] 2.69Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RAA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7raa]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RAA FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7raa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7raa OCA], [https://pdbe.org/7raa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7raa RCSB], [https://www.ebi.ac.uk/pdbsum/7raa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7raa ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7raa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7raa OCA], [https://pdbe.org/7raa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7raa RCSB], [https://www.ebi.ac.uk/pdbsum/7raa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7raa ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Chu | + | [[Category: Chu, A E]] |
| - | [[Category: Garcia | + | [[Category: Garcia, K C]] |
| - | [[Category: Huang P | + | [[Category: Huang, P S]] |
| - | [[Category: Jude | + | [[Category: Jude, K M]] |
| + | [[Category: Computational design]] | ||
| + | [[Category: Cytokine]] | ||
Revision as of 11:59, 23 March 2022
Designed StabIL-2 seq15
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