1gp2

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[[Image:1gp2.gif|left|200px]]
[[Image:1gp2.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1gp2| PDB=1gp2 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gp2 OCA], [http://www.ebi.ac.uk/pdbsum/1gp2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gp2 RCSB]</span>
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'''G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND'''
'''G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND'''
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[[Category: Sprang, S R.]]
[[Category: Sprang, S R.]]
[[Category: Wall, M A.]]
[[Category: Wall, M A.]]
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[[Category: complex (gtp-binding/transducer)]]
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[[Category: Gtpase]]
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[[Category: gtpase]]
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[[Category: Ras-like]]
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[[Category: ras-like]]
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[[Category: Signal transduction protein]]
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[[Category: signal transduction protein]]
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[[Category: Wd40]]
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[[Category: wd40]]
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Revision as of 14:50, 2 May 2008

Image:1gp2.gif

Template:STRUCTURE 1gp2

G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND


Overview

The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma. The major alpha/beta interface covers switch II of alpha, and GTP-induced rearrangement of switch II causes subunit dissociation during signaling. Alterations in GDP binding in the heterotrimer (compared with alpha-GDP) explain stabilization of the inactive conformation of alpha by beta gamma. Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade.

About this Structure

1GP2 is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2., Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR, Cell. 1995 Dec 15;83(6):1047-58. PMID:8521505 Page seeded by OCA on Fri May 2 17:50:33 2008

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