2v1u

From Proteopedia

(Difference between revisions)

Revision as of 12:36, 23 March 2022

STRUCTURE OF THE AEROPYRUM PERNIX ORC1 PROTEIN IN COMPLEX WITH DNA

Structural highlights

2v1u is a 3 chain structure with sequence from Aeropyrum pernix. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CDC6_AERPE] Might be involved in the initiation of DNA replication (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

DNA replication in archaea and in eukaryotes share many similarities. We report the structure of an archaeal origin recognition complex protein, ORC1, bound to an origin recognition box, a DNA sequence that is found in multiple copies at replication origins. DNA binding is mediated principally by a C-terminal winged helix domain that inserts deeply into the major and minor grooves, widening them both. However, additional DNA contacts are made with the N-terminal AAA+ domain, which inserts into the minor groove at a characteristic G-rich sequence, inducing a 35 degrees bend in the duplex and providing directionality to the binding site. Both contact regions also induce substantial unwinding of the DNA. The structure provides insight into the initial step in assembly of a replication origin and recruitment of minichromosome maintenance (MCM) helicase to that origin.

Structural basis of DNA replication origin recognition by an ORC protein.,Gaudier M, Schuwirth BS, Westcott SL, Wigley DB Science. 2007 Aug 31;317(5842):1213-6. PMID:17761880^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Gaudier M, Schuwirth BS, Westcott SL, Wigley DB. Structural basis of DNA replication origin recognition by an ORC protein. Science. 2007 Aug 31;317(5842):1213-6. PMID:17761880 doi:317/5842/1213

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2v1u"

@@ Line 3: / Line 3: @@
 <StructureSection load='2v1u' size='340' side='right'caption='[[2v1u]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2v1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V1U OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V1U FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2v1u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V1U FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v1u OCA], [http://pdbe.org/2v1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v1u RCSB], [http://www.ebi.ac.uk/pdbsum/2v1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v1u ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v1u OCA], [https://pdbe.org/2v1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v1u RCSB], [https://www.ebi.ac.uk/pdbsum/2v1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v1u ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CDC6_AERPE CDC6_AERPE]] Might be involved in the initiation of DNA replication (By similarity).
+[[https://www.uniprot.org/uniprot/CDC6_AERPE CDC6_AERPE]] Might be involved in the initiation of DNA replication (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

2v1u

From Proteopedia

Revision as of 12:36, 23 March 2022

STRUCTURE OF THE AEROPYRUM PERNIX ORC1 PROTEIN IN COMPLEX WITH DNA

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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