1gpf

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[[Image:1gpf.gif|left|200px]]
[[Image:1gpf.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1gpf |SIZE=350|CAPTION= <scene name='initialview01'>1gpf</scene>, resolution 1.85&Aring;
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The line below this paragraph, containing "STRUCTURE_1gpf", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1gpf| PDB=1gpf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gpf OCA], [http://www.ebi.ac.uk/pdbsum/1gpf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gpf RCSB]</span>
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}}
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'''CHITINASE B FROM SERRATIA MARCESCENS IN COMPLEX WITH INHIBITOR PSAMMAPLIN'''
'''CHITINASE B FROM SERRATIA MARCESCENS IN COMPLEX WITH INHIBITOR PSAMMAPLIN'''
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[[Category: Aalten, D M.Van.]]
[[Category: Aalten, D M.Van.]]
[[Category: Komander, D.]]
[[Category: Komander, D.]]
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[[Category: chitin degradation]]
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[[Category: Chitin degradation]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: inhibitor psammaplin]]
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[[Category: Inhibitor psammaplin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:51:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:48:45 2008''
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Revision as of 14:51, 2 May 2008

Image:1gpf.gif

Template:STRUCTURE 1gpf

CHITINASE B FROM SERRATIA MARCESCENS IN COMPLEX WITH INHIBITOR PSAMMAPLIN


Overview

Several brominated tyrosine derived compounds, psammaplins A (1), K (2) and L (3) as well as bisaprasin (4) were isolated from the Fijian marine sponge Aplysinella rhax during a bioassay guided isolation protocol. Their structures were determined using NMR and MS techniques. Psammaplin A was found to moderately inhibit chitinase B from Serratia marcescens, the mode of inhibition being non-competitive. Crystallographic studies suggest that a disordered psammaplin A molecule is bound near the active site. Interestingly, psammaplin A was found to be a potent antifungal agent.

About this Structure

1GPF is a Single protein structure of sequence from Serratia marcescens. Full crystallographic information is available from OCA.

Reference

Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax., Tabudravu JN, Eijsink VG, Gooday GW, Jaspars M, Komander D, Legg M, Synstad B, van Aalten DM, Bioorg Med Chem. 2002 Apr;10(4):1123-8. PMID:11836123 Page seeded by OCA on Fri May 2 17:51:18 2008

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