Sandbox Reserved 1713

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<scene name='90/904318/Alkalbindingsurfacewmembrane/1'>Binding surface of ALKAL with the membrane</scene>
<scene name='90/904318/Alkalbindingsurfacewmembrane/1'>Binding surface of ALKAL with the membrane</scene>
<scene name='90/904318/Alkal1membraneinteraction/2'>ALKAL's residues that interact with membrane</scene>
<scene name='90/904318/Alkal1membraneinteraction/2'>ALKAL's residues that interact with membrane</scene>
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===Conformational Change===
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In order for the Anaplastic Lymphoma Kinase (ALK) to move across the membrane to bind with the second monomer, it has to undergo a conformational change. The Anaplastic Lymphoma Kinase Activating Ligand (ALKAL) binds to the binding surface on the ALK. This induces a conformational change which allows for the PXL and the GlyR domains to hinge forward. <ref>DOI: 10.1038/s41586-021-04140-8</ref> The kinase is now ready to move across the membrane and attach to the other kinase to be fully activated.
== Disease ==
== Disease ==
<scene name='90/904318/Premutationresidues/1'>residues that are mutated</scene>
<scene name='90/904318/Premutationresidues/1'>residues that are mutated</scene>
== Relevance ==
== Relevance ==
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<ref>DOI: 10.1038/s41586-021-04140-8</ref>
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== Structural highlights ==
== Structural highlights ==

Revision as of 20:14, 27 March 2022

This Sandbox is Reserved from February 28 through September 1, 2022 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1700 through Sandbox Reserved 1729.
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Anaplastic Lymphoma Kinase

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References

  1. ↑ Reshetnyak AV, Rossi P, Myasnikov AG, Sowaileh M, Mohanty J, Nourse A, Miller DJ, Lax I, Schlessinger J, Kalodimos CG. Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature. 2021 Dec;600(7887):153-157. doi: 10.1038/s41586-021-04140-8. Epub 2021, Nov 24. PMID:34819673 doi:http://dx.doi.org/10.1038/s41586-021-04140-8
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