Sandbox Reserved 1712

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<StructureSection load='7n00' size='350' frame='true'side='right' caption='Anaplastic Lymphoma Kinase' scene=’’>
<StructureSection load='7n00' size='350' frame='true'side='right' caption='Anaplastic Lymphoma Kinase' scene=’’>
Anaplastic Lymphoma Kinase is a receptor tyrosine [https://pubmed.ncbi.nlm.nih.gov/32114309/ kinase]. ALK transfers a phosphate group from [https://www.ncbi.nlm.nih.gov/books/NBK553175/ ATP] to a tyrosine residue on an enzyme which activates a signaling cascade, and ALK becomes activated when a ligand called [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789956/ ALKAL] binds to the binding surface on an extracellular domain of ALK. ALK is an integral membrane protein.
Anaplastic Lymphoma Kinase is a receptor tyrosine [https://pubmed.ncbi.nlm.nih.gov/32114309/ kinase]. ALK transfers a phosphate group from [https://www.ncbi.nlm.nih.gov/books/NBK553175/ ATP] to a tyrosine residue on an enzyme which activates a signaling cascade, and ALK becomes activated when a ligand called [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789956/ ALKAL] binds to the binding surface on an extracellular domain of ALK. ALK is an integral membrane protein.
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<ref>DOI: 10.3390/ijms19113448</ref>
== Function ==
== Function ==
[[Image:Prote_ALK_Monomer_White.png|400 px|right|thumb|Figure 1]]
[[Image:Prote_ALK_Monomer_White.png|400 px|right|thumb|Figure 1]]

Revision as of 01:58, 28 March 2022

This Sandbox is Reserved from February 28 through September 1, 2022 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1700 through Sandbox Reserved 1729.
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Anaplastic Lymphoma Kinase

Anaplastic Lymphoma Kinase

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References

  1. Huang H. Anaplastic Lymphoma Kinase (ALK) Receptor Tyrosine Kinase: A Catalytic Receptor with Many Faces. Int J Mol Sci. 2018 Nov 2;19(11). pii: ijms19113448. doi: 10.3390/ijms19113448. PMID:30400214 doi:http://dx.doi.org/10.3390/ijms19113448
  2. Reshetnyak AV, Rossi P, Myasnikov AG, Sowaileh M, Mohanty J, Nourse A, Miller DJ, Lax I, Schlessinger J, Kalodimos CG. Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature. 2021 Dec;600(7887):153-157. doi: 10.1038/s41586-021-04140-8. Epub 2021, Nov 24. PMID:34819673 doi:http://dx.doi.org/10.1038/s41586-021-04140-8
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