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G-Protein Coupled Receptors

G-protein coupled receptors(GCPRs) are a large family of cell surface membrane proteins. Once bound to a wide variety of extracellular ligands, GCPRs undergo a conformational change and relay information to intracellular secondary messengers¹. This G protein activation results in a cellular response dependent on the ligand bound and location of the GPCR in the body. GCPRs can be broken down into five families: the rhodopsin family (class A, 701 members), the secretin family (class B, 15 members), the adhesion family (24 members), the glutamate family (class C, 15 members), and the frizzled/taste family (class F, 24 members)². All of the families have a similar transmembrane (TM) domain consisting of seven ɑ-helices complexed with intracellular G proteins.

Class A GCPRs

Class A GPCRS or rhodopsin-like GPCRS are the largest and most studied type of GPCRS. Due to the diversity of these receptors they are found in many aspects of physiology. They are characterized by conserved motifs including DRY, PIF, Sodium Binding, and the CWxP.6 A common example of a class A GPCRS is the β2AR receptor (PDB: 3sn6).

MRGPRs

MRGPRX2 General

Structure with Structure with

Types of Ligand Bound

Cation

Peptide

Specific Traits

Disulfide bonds

Toggle Switch

PIF Motif

DRY Motif

Sodium Binding

MRGPRX2 Signaling Pathway

Function

Conformational Changes

What It Triggers

Clinical Relevance

Drugs

References

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