1gqv

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[[Image:1gqv.jpg|left|200px]]
[[Image:1gqv.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1gqv |SIZE=350|CAPTION= <scene name='initialview01'>1gqv</scene>, resolution 0.98&Aring;
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The line below this paragraph, containing "STRUCTURE_1gqv", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:P-1+Peripheral+Subsite+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1gqv| PDB=1gqv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gqv OCA], [http://www.ebi.ac.uk/pdbsum/1gqv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gqv RCSB]</span>
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}}
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'''ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN'''
'''ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN'''
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[[Category: Swaminathan, G J.]]
[[Category: Swaminathan, G J.]]
[[Category: Veluraja, K.]]
[[Category: Veluraja, K.]]
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[[Category: ribonuclease]]
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[[Category: Ribonuclease]]
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[[Category: rnase us]]
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[[Category: Rnase us]]
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[[Category: rnase-2]]
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[[Category: Rnase-2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:54:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:49:43 2008''
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Revision as of 14:54, 2 May 2008

Image:1gqv.jpg

Template:STRUCTURE 1gqv

ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN


Overview

Human eosinophil-derived neurotoxin (EDN) is a small, basic protein that belongs to the ribonuclease A superfamily. EDN displays antiviral activity and causes the neurotoxic Gordon phenomenon when injected into rabbits. Although EDN and ribonuclease A have appreciable structural similarity and a conserved catalytic triad, their peripheral substrate-binding sites are not conserved. The crystal structure of recombinant EDN (rEDN) has been determined at 0.98 A resolution from data collected at a low temperature (100 K). We have refined the crystallographic model of the structure using anisotropic displacement parameters to a conventional R-factor of 0.116. This represents the highest resolution structure of rEDN determined to date and is only the second ribonuclease structure to be determined at a resolution greater than 1.0 A. The structure provides a detailed picture of the conformational freedom at the various subsites of rEDN, and the water structure accounts for more than 50% of the total solvent content of the unit cell. This information will be crucial for the design of tight-binding inhibitors to restrain the ribonucleolytic activity of rEDN.

About this Structure

1GQV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Atomic resolution (0.98 A) structure of eosinophil-derived neurotoxin., Swaminathan GJ, Holloway DE, Veluraja K, Acharya KR, Biochemistry. 2002 Mar 12;41(10):3341-52. PMID:11876642 Page seeded by OCA on Fri May 2 17:54:33 2008

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