7exy
From Proteopedia
(Difference between revisions)
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==T-hairpin structure found in the RNA element involved in the piRNA biogenesis== | ==T-hairpin structure found in the RNA element involved in the piRNA biogenesis== | ||
| - | <StructureSection load='7exy' size='340' side='right'caption='[[7exy]]' scene=''> | + | <StructureSection load='7exy' size='340' side='right'caption='[[7exy]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7exy]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EXY FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7exy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7exy OCA], [https://pdbe.org/7exy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7exy RCSB], [https://www.ebi.ac.uk/pdbsum/7exy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7exy ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7exy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7exy OCA], [https://pdbe.org/7exy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7exy RCSB], [https://www.ebi.ac.uk/pdbsum/7exy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7exy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | PIWI-interacting RNAs (piRNAs) repress transposons to protect the germline genome from DNA damage caused by transposon transposition. In Drosophila, the Traffic jam (Tj) mRNA is consumed to produce piRNA in its 3' UTR. A cis element located within the 3'-UTR, Tj-cis, is necessary for piRNA biogenesis. In this study, we analyzed the structure of the Tj-cis RNA, a 100 nt RNA corresponding to the Tj-cis element, by the SHAPE and NMR analyses and found that a stable hairpin structure formed in the 5' half of the Tj-cis RNA. The tertiary structure of the 16 nt stable hairpin was analyzed by NMR, and a novel stem-loop structure, the T-hairpin, was found. In the T-hairpin, four uridine residues are exposed to the solvent, suggesting that this stem loop is the target of Yb protein, a Tudor domain-containing piRNA biogenesis factor. The piRNA biogenesis assay showed that both the T-hairpin and the 3' half are required for the function of the Tj-cis element, suggesting that both the T-hairpin and the 3' half are recognized by Yb protein. | ||
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| + | T-hairpin structure found in the RNA element involved in piRNA biogenesis.,Takase N, Otsu M, Hirakata S, Ishizu H, Siomi MC, Kawai G RNA. 2022 Jan 5. pii: rna.078967.121. doi: 10.1261/rna.078967.121. PMID:34987083<ref>PMID:34987083</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7exy" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Kawai G]] | + | [[Category: Kawai, G]] |
| - | [[Category: Takase N]] | + | [[Category: Takase, N]] |
| + | [[Category: Cis element]] | ||
| + | [[Category: Pirna]] | ||
| + | [[Category: Rna]] | ||
Revision as of 11:12, 30 March 2022
T-hairpin structure found in the RNA element involved in the piRNA biogenesis
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Categories: Large Structures | Kawai, G | Takase, N | Cis element | Pirna | Rna
