7r6o
From Proteopedia
(Difference between revisions)
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==Pyrrolysyl-tRNA synthetase from methanogenic archaeon ISO4-G1 (G1PylRS)== | ==Pyrrolysyl-tRNA synthetase from methanogenic archaeon ISO4-G1 (G1PylRS)== | ||
| - | <StructureSection load='7r6o' size='340' side='right'caption='[[7r6o]]' scene=''> | + | <StructureSection load='7r6o' size='340' side='right'caption='[[7r6o]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R6O FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7r6o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R6O FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r6o OCA], [https://pdbe.org/7r6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r6o RCSB], [https://www.ebi.ac.uk/pdbsum/7r6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r6o ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r6o OCA], [https://pdbe.org/7r6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r6o RCSB], [https://www.ebi.ac.uk/pdbsum/7r6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r6o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cyanopyridylalanines are non-canonical amino acids that react with aminothiol compounds under physiological conditions in a biocompatible manner without requiring added catalyst. Here we present newly developed aminoacyl-tRNA synthetases for genetic encoding of meta- and para-cyanopyridylalanine to enable the site-specific attachment of a wide range of different functionalities. The outstanding utility of the cyanopyridine moiety is demonstrated by examples of i) post-translational functionalization of proteins, ii) in-cell macrocyclization of peptides and proteins, and iii) protein stapling. The biocompatible nature of the protein ligation chemistry enabled by the cyanopyridylalanine amino acid opens a new path to specific in vivo protein modifications in complex biological environments. | ||
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| + | Genetic Encoding of Cyanopyridylalanine for In-Cell Protein Macrocyclization by the Nitrile-Aminothiol Click Reaction.,Abdelkader EH, Qianzhu H, George J, Frkic RL, Jackson CJ, Nitsche C, Otting G, Huber T Angew Chem Int Ed Engl. 2022 Jan 31:e202114154. doi: 10.1002/anie.202114154. PMID:35102680<ref>PMID:35102680</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7r6o" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Frkic | + | [[Category: Frkic, R L]] |
| - | [[Category: Huber T]] | + | [[Category: Huber, T]] |
| - | [[Category: Jackson | + | [[Category: Jackson, C J]] |
| + | [[Category: Translation]] | ||
| + | [[Category: Trna synthetase]] | ||
| + | [[Category: Trna synthetases class ii]] | ||
| + | [[Category: Trna-ligase]] | ||
Revision as of 11:16, 30 March 2022
Pyrrolysyl-tRNA synthetase from methanogenic archaeon ISO4-G1 (G1PylRS)
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