1gri

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[[Image:1gri.gif|left|200px]]
[[Image:1gri.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1gri", creates the "Structure Box" on the page.
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|GENE= HGRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gri OCA], [http://www.ebi.ac.uk/pdbsum/1gri PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gri RCSB]</span>
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'''GRB2'''
'''GRB2'''
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[[Category: Ducruix, A.]]
[[Category: Ducruix, A.]]
[[Category: Maignan, S.]]
[[Category: Maignan, S.]]
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[[Category: sh2]]
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[[Category: Sh2]]
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[[Category: sh3]]
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[[Category: Sh3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:49:54 2008''
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Revision as of 14:55, 2 May 2008

Image:1gri.gif

Template:STRUCTURE 1gri

GRB2


Overview

The mammalian growth factor receptor-binding protein Grb2 is an adaptor that mediates activation of guanine nucleotide exchange on Ras. Grb2 binds to the receptor through its SH2 domain and to the carboxyl-terminal domain of Son of sevenless through its two SH3 domains. It is thus a key element in the signal transduction pathway. The crystal structure of Grb2 was determined to 3.1 angstrom resolution. The asymmetric unit is composed of an embedded dimer. The interlaced junctions between the SH2 and SH3 domains bring the two adjacent faces of the SH3 domains in van der Waals contact but leave room for the binding of proline-rich peptides.

About this Structure

1GRI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the mammalian Grb2 adaptor., Maignan S, Guilloteau JP, Fromage N, Arnoux B, Becquart J, Ducruix A, Science. 1995 Apr 14;268(5208):291-3. PMID:7716522 Page seeded by OCA on Fri May 2 17:55:35 2008

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