2w3c

From Proteopedia

(Difference between revisions)

Revision as of 11:52, 30 March 2022

Globular head region of the human general vesicular transport factor p115

Structural highlights

2w3c is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[USO1_HUMAN] General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The golgin family gives identity and structure to the Golgi apparatus and is part of a complex protein network at the Golgi membrane. The golgin p115 is targeted by the GTPase Rab1a, contains a large globular head region and a long region of coiled-coil which forms an extended rod-like structure. p115 serves as vesicle tethering factor and plays an important role at different steps of vesicular transport. Here we present the 2.2 A-resolution X-ray structure of the globular head region of p115. The structure exhibits an armadillo fold that is decorated by elongated loops and carries a C-terminal non-canonical repeat. This terminal repeat folds into the armadillo superhelical groove and allows homodimeric association with important implications for p115 mediated multiple protein interactions and tethering.

Unusual armadillo fold in the human general vesicular transport factor p115.,Striegl H, Roske Y, Kummel D, Heinemann U PLoS ONE. 2009;4(2):e4656. Epub 2009 Feb 27. PMID:19247479^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Striegl H, Roske Y, Kummel D, Heinemann U. Unusual armadillo fold in the human general vesicular transport factor p115. PLoS ONE. 2009;4(2):e4656. Epub 2009 Feb 27. PMID:19247479 doi:10.1371/journal.pone.0004656

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2w3c"

@@ Line 3: / Line 3: @@
 <StructureSection load='2w3c' size='340' side='right'caption='[[2w3c]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2w3c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W3C FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2w3c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3C FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3c OCA], [http://pdbe.org/2w3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w3c RCSB], [http://www.ebi.ac.uk/pdbsum/2w3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3c ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3c OCA], [https://pdbe.org/2w3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3c RCSB], [https://www.ebi.ac.uk/pdbsum/2w3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3c ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/USO1_HUMAN USO1_HUMAN]] General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity).
+[[https://www.uniprot.org/uniprot/USO1_HUMAN USO1_HUMAN]] General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

2w3c

From Proteopedia

Revision as of 11:52, 30 March 2022

Globular head region of the human general vesicular transport factor p115

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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