1gru

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[[Image:1gru.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gru OCA], [http://www.ebi.ac.uk/pdbsum/1gru PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gru RCSB]</span>
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'''SOLUTION STRUCTURE OF GROES-ADP7-GROEL-ATP7 COMPLEX BY CRYO-EM'''
'''SOLUTION STRUCTURE OF GROES-ADP7-GROEL-ATP7 COMPLEX BY CRYO-EM'''
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[[Category: Roseman, A M.]]
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[[Category: Saibil, H R.]]
[[Category: Saibil, H R.]]
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[[Category: Adp]]
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[[Category: atp]]
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[[Category: Atp]]
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[[Category: roe]]
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[[Category: Roe]]
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[[Category: hsp60]]
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[[Category: Hsp60]]
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[[Category: molecular chaperone]]
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[[Category: Molecular chaperone]]
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Revision as of 14:56, 2 May 2008

Image:1gru.gif

Template:STRUCTURE 1gru

SOLUTION STRUCTURE OF GROES-ADP7-GROEL-ATP7 COMPLEX BY CRYO-EM


Overview

The chaperonin GroEL drives its protein-folding cycle by cooperatively binding ATP to one of its two rings, priming that ring to become folding-active upon GroES binding, while simultaneously discharging the previous folding chamber from the opposite ring. The GroEL-ATP structure, determined by cryo-EM and atomic structure fitting, shows that the intermediate domains rotate downward, switching their intersubunit salt bridge contacts from substrate binding to ATP binding domains. These observations, together with the effects of ATP binding to a GroEL-GroES-ADP complex, suggest structural models for the ATP-induced reduction in affinity for polypeptide and for cooperativity. The model for cooperativity, based on switching of intersubunit salt bridge interactions around the GroEL ring, may provide general insight into cooperativity in other ring complexes and molecular machines.

About this Structure

1GRU is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

ATP-bound states of GroEL captured by cryo-electron microscopy., Ranson NA, Farr GW, Roseman AM, Gowen B, Fenton WA, Horwich AL, Saibil HR, Cell. 2001 Dec 28;107(7):869-79. PMID:11779463 Page seeded by OCA on Fri May 2 17:56:06 2008

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