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3hrr

From Proteopedia

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==The Product Template Domain from PksA with Harris Compound Bound==
==The Product Template Domain from PksA with Harris Compound Bound==
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<StructureSection load='3hrr' size='340' side='right' caption='[[3hrr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='3hrr' size='340' side='right'caption='[[3hrr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hrr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Asppa Asppa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HRR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hrr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Asppa Asppa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HRR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC8:1-(3-ACETYL-4,5-DIHYDROXY-7-METHOXYNAPHTHALEN-2-YL)PROPAN-2-ONE'>HC8</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC8:1-(3-ACETYL-4,5-DIHYDROXY-7-METHOXYNAPHTHALEN-2-YL)PROPAN-2-ONE'>HC8</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hrq|3hrq]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3hrq|3hrq]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PksA, pksL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5067 ASPPA])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PksA, pksL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5067 ASPPA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hrr OCA], [http://pdbe.org/3hrr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hrr RCSB], [http://www.ebi.ac.uk/pdbsum/3hrr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hrr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hrr OCA], [https://pdbe.org/3hrr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hrr RCSB], [https://www.ebi.ac.uk/pdbsum/3hrr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hrr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PKSL1_ASPPA PKSL1_ASPPA]] Combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor norsolorinic acid anthrone (noranthrone) in the aflatoxin biosynthesis pathway. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase.<ref>PMID:15006741</ref> <ref>PMID:18403714</ref>
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[[https://www.uniprot.org/uniprot/PKSL1_ASPPA PKSL1_ASPPA]] Combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor norsolorinic acid anthrone (noranthrone) in the aflatoxin biosynthesis pathway. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase.<ref>PMID:15006741</ref> <ref>PMID:18403714</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/3hrr_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/3hrr_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</StructureSection>
</StructureSection>
[[Category: Asppa]]
[[Category: Asppa]]
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[[Category: Large Structures]]
[[Category: Korman, T P]]
[[Category: Korman, T P]]
[[Category: Tsai, S C]]
[[Category: Tsai, S C]]

Revision as of 11:55, 30 March 2022

The Product Template Domain from PksA with Harris Compound Bound

PDB ID 3hrr

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