User:Anna Postnikova/MAT
From Proteopedia
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<scene name='90/907472/Mat2a/4'>MATa2 Subunit</scene> | <scene name='90/907472/Mat2a/4'>MATa2 Subunit</scene> | ||
| - | MAT consists of | + | MAT consists of α and β subunits. MATα1 and MATα2 are catalytic subunits while MATβ is a regulatory subunit. The subunits are encoded on different genes in humans, so they are created separately and can then come together to form various complexes, such as MATαβ or MATα2 dimers <ref>Murray et al.</ref> |
| - | == | + | == Other Substrates == |
== Relevance == | == Relevance == | ||
Revision as of 13:48, 4 April 2022
Contents |
Methionine adenosyltransferase
MAT synthesizes S-adenosylmethionine from the substrates ATP and methionine. ATP isn’t used as a source of energy like it is in other reactions but gets a methionine added onto the 5th carbon while the three phosphate groups are broken down and released from the active sit. This enzyme is conserved and found in many organisms, so it is essential for life. Problems with this enzyme have been shown to cause diseases such as various cancers.
SAM Formation Mechanism
Function
Structure
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References
- ↑ Murray et al.
