1gt9

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[[Image:1gt9.jpg|left|200px]]
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{{Structure
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|PDB= 1gt9 |SIZE=350|CAPTION= <scene name='initialview01'>1gt9</scene>, resolution 1.38&Aring;
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|SITE= <scene name='pdbsite=CA1:Ca+Binding+Site+For+Chain+2'>CA1</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_1gt9| PDB=1gt9 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt9 OCA], [http://www.ebi.ac.uk/pdbsum/1gt9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gt9 RCSB]</span>
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'''HIGH RESOLUTION CRYSTAL STRUCTURE OF A THERMOSTABLE SERINE-CARBOXYL TYPE PROTEINASE'''
'''HIGH RESOLUTION CRYSTAL STRUCTURE OF A THERMOSTABLE SERINE-CARBOXYL TYPE PROTEINASE'''
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[[Category: Oyama, H.]]
[[Category: Oyama, H.]]
[[Category: Uchida, K.]]
[[Category: Uchida, K.]]
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[[Category: serine-carboxyl type proteinase]]
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[[Category: Serine-carboxyl type proteinase]]
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[[Category: thermostable]]
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[[Category: Thermostable]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:58:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:50:55 2008''
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Revision as of 14:58, 2 May 2008

Image:1gt9.jpg

Template:STRUCTURE 1gt9

HIGH RESOLUTION CRYSTAL STRUCTURE OF A THERMOSTABLE SERINE-CARBOXYL TYPE PROTEINASE


Overview

Kumamolysin is a thermostable endopeptidase from Bacillus novosp. MN-32, exhibiting maximal proteolytic activity around pH 3. It belongs to the newly identified family of serine-carboxyl proteinases, which also includes CLN2, a human lysosomal homolog recently implicated in a fatal neurodegenerative disease. Kumamolysin and its complexes with two aldehyde inhibitors were crystallized, and their three-dimensional structures were solved and refined with X-ray data to 1.4 A resolution. As its Pseudomonas homolog, kumamolysin exhibits a Ser/Glu/Asp catalytic triad with particularly short interconnecting hydrogen bonds and an oxyanion hole enabling the reactive serine to attack substrate peptide bonds at quite acidic pH. An additional Glu/Trp pair, unique to kumamolysin, might further facilitate proton delocalization during nucleophilic attack, in particular at high temperature.

About this Structure

1GT9 is a Single protein structure of sequence from Bacteria. Full crystallographic information is available from OCA.

Reference

The 1.4 a crystal structure of kumamolysin: a thermostable serine-carboxyl-type proteinase., Comellas-Bigler M, Fuentes-Prior P, Maskos K, Huber R, Oyama H, Uchida K, Dunn BM, Oda K, Bode W, Structure. 2002 Jun;10(6):865-76. PMID:12057200 Page seeded by OCA on Fri May 2 17:58:43 2008

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