7dv5
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Human bile salt exporter ABCB11 in complex with taurocholate== | ==Human bile salt exporter ABCB11 in complex with taurocholate== | ||
| - | <StructureSection load='7dv5' size='340' side='right'caption='[[7dv5]]' scene=''> | + | <StructureSection load='7dv5' size='340' side='right'caption='[[7dv5]], [[Resolution|resolution]] 3.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DV5 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7dv5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DV5 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dv5 OCA], [https://pdbe.org/7dv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dv5 RCSB], [https://www.ebi.ac.uk/pdbsum/7dv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dv5 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dv5 OCA], [https://pdbe.org/7dv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dv5 RCSB], [https://www.ebi.ac.uk/pdbsum/7dv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dv5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN]] Progressive familial intrahepatic cholestasis type 2;Intrahepatic cholestasis of pregnancy;Benign recurrent intrahepatic cholestasis type 2. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN]] Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner (PubMed:16332456). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456).<ref>PMID:16332456</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Chen Y]] | + | [[Category: Chen, Y]] |
| - | [[Category: How | + | [[Category: How, W T]] |
| - | [[Category: Wang L]] | + | [[Category: Wang, L]] |
| + | [[Category: Abc transporter]] | ||
| + | [[Category: Liver]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Translocase]] | ||
Revision as of 10:30, 6 April 2022
Human bile salt exporter ABCB11 in complex with taurocholate
| |||||||||||
