7e1a
From Proteopedia
(Difference between revisions)
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==Human bile salt exporter ABCB11 in complex with taurocholate== | ==Human bile salt exporter ABCB11 in complex with taurocholate== | ||
| - | <StructureSection load='7e1a' size='340' side='right'caption='[[7e1a]]' scene=''> | + | <StructureSection load='7e1a' size='340' side='right'caption='[[7e1a]], [[Resolution|resolution]] 3.66Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E1A FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7e1a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E1A FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e1a OCA], [https://pdbe.org/7e1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e1a RCSB], [https://www.ebi.ac.uk/pdbsum/7e1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e1a ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e1a OCA], [https://pdbe.org/7e1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e1a RCSB], [https://www.ebi.ac.uk/pdbsum/7e1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e1a ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN]] Progressive familial intrahepatic cholestasis type 2;Intrahepatic cholestasis of pregnancy;Benign recurrent intrahepatic cholestasis type 2. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN]] Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner (PubMed:16332456). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456).<ref>PMID:16332456</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Chen Y]] | + | [[Category: Chen, Y]] |
| - | [[Category: How | + | [[Category: How, W T]] |
| - | [[Category: Wang L]] | + | [[Category: Wang, L]] |
| + | [[Category: Abc transporter]] | ||
| + | [[Category: Liver]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 10:30, 6 April 2022
Human bile salt exporter ABCB11 in complex with taurocholate
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