1gtr

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[[Image:1gtr.jpg|left|200px]]
[[Image:1gtr.jpg|left|200px]]
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{{Structure
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|PDB= 1gtr |SIZE=350|CAPTION= <scene name='initialview01'>1gtr</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1gtr", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1gtr| PDB=1gtr | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gtr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gtr OCA], [http://www.ebi.ac.uk/pdbsum/1gtr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gtr RCSB]</span>
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}}
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'''STRUCTURAL BASIS OF ANTICODON LOOP RECOGNITION BY GLUTAMINYL-TRNA SYNTHETASE'''
'''STRUCTURAL BASIS OF ANTICODON LOOP RECOGNITION BY GLUTAMINYL-TRNA SYNTHETASE'''
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[[Category: Rould, M A.]]
[[Category: Rould, M A.]]
[[Category: Steitz, T A.]]
[[Category: Steitz, T A.]]
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[[Category: complex (ligase/trna)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:59:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:51:10 2008''
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Revision as of 14:59, 2 May 2008

Image:1gtr.jpg

Template:STRUCTURE 1gtr

STRUCTURAL BASIS OF ANTICODON LOOP RECOGNITION BY GLUTAMINYL-TRNA SYNTHETASE


Overview

The refined crystal structure of Escherichia coli glutaminyl transfer RNA synthetase complexed with transfer RNA(Gln) and ATP reveals that the structure of the anticodon loop of the enzyme-bound tRNA(Gln) differs extensively from that of the known crystal structures of uncomplexed tRNA molecules. The anticodon stem is extended by two non-Watson-Crick base pairs, leaving the three anti-codon bases unpaired and splayed out to bind snugly into three separate complementary pockets in the protein. These interactions suggest that the entire anticodon loop provides essential sites for glutaminyl tRNA synthetase discrimination among tRNA molecules.

About this Structure

1GTR is a Single protein structure of sequence from Escherichia coli. The following page contains interesting information on the relation of 1GTR with [Aminoacyl-tRNA Synthetases]. Full crystallographic information is available from OCA.

Reference

Structural basis of anticodon loop recognition by glutaminyl-tRNA synthetase., Rould MA, Perona JJ, Steitz TA, Nature. 1991 Jul 18;352(6332):213-8. PMID:1857417 Page seeded by OCA on Fri May 2 17:59:51 2008

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