2wr6
From Proteopedia
(Difference between revisions)
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<StructureSection load='2wr6' size='340' side='right'caption='[[2wr6]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2wr6' size='340' side='right'caption='[[2wr6]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2wr6]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2wr6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WR6 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ODT:(11E,13E,15Z)-OCTADECA-11,13,15-TRIENOIC+ACID'>ODT</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ODT:(11E,13E,15Z)-OCTADECA-11,13,15-TRIENOIC+ACID'>ODT</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rbp|1rbp]], [[1jyd|1jyd]], [[1jyj|1jyj]], [[2wq9|2wq9]], [[1qab|1qab]], [[2wqa|2wqa]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rbp|1rbp]], [[1jyd|1jyd]], [[1jyj|1jyj]], [[2wq9|2wq9]], [[1qab|1qab]], [[2wqa|2wqa]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wr6 OCA], [https://pdbe.org/2wr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wr6 RCSB], [https://www.ebi.ac.uk/pdbsum/2wr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wr6 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[https://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 11:14, 6 April 2022
Structure of the complex of RBP4 with linoleic acid
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