User:Michael O'Shaughnessy/ TS

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<scene name='90/907470/Ts/2'>TS with no DDT or UMP</scene>
<scene name='90/907470/Ts/2'>TS with no DDT or UMP</scene>
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<ref>doi.org/10.1016/S1074-5521(01)00067-9</ref>
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<ref>DOI 10.1016/S1074-5521(01)00067-9</ref>

Revision as of 14:34, 6 April 2022

Thymidylate Synthase

Overview

The enzyme thymidylate synthase catalyzes the transfer of a methyl group and a hydride from 5,10-methylenetetrahydrofolate to 2-deoxyuridine-5'-monophosphate, resulting in the formation of thymidine 5'-monophosphate and dihydrofolate. This is the only de novo source of dTMP in humans.

2-deoxyuridine-5'-monophosphate(dUMP) + 5, 10-methylenetetrahydrofolate(CH2H4F) ⇌ thymidine 5'-monophosphate(dTMP) + Dihydrofolate(H2F)

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ doi: https://dx.doi.org/10.1016/S1074-5521(01)00067-9

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Michael O'Shaughnessy

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