Stimulator of interferon genes
From Proteopedia
(Difference between revisions)
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[[Stimulator of interferon genes protein 3D structures]] | [[Stimulator of interferon genes protein 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of stimulator of interferon genes protein== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *Stimulator of interferon genes protein; domains - C-di-GMP-binding 154-341; PLPLRT/SD motif 342-379 | ||
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| - | **[[6nt5]] – hSTING - human - Cryo EM<br /> | ||
| - | **[[4ef5]], [[4f5w]], [[4f9e]] – hSTING C-di-GMP-binding domain<br /> | ||
| - | **[[4f5e]], [[6mx0]] – hSTING C-di-GMP-binding domain (mutant)<br /> | ||
| - | **[[6iyf]] – pSTING C-di-GMP-binding domain - pig<br /> | ||
| - | **[[4kc0]] – mSTING C-di-GMP-binding domain - mouse<br /> | ||
| - | **[[5gs5]] – rSTING C-di-GMP-binding domain - rat<br /> | ||
| - | **[[6nt6]] – cSTING - chicken - Cryo EM<br /> | ||
| - | **[[5cfo]], [[5cfr]] – aSTING – anemone<br /> | ||
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| - | *Stimulator of interferon genes protein complex | ||
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| - | **[[4ef4]], [[4emt]], [[4emu]], [[4f5y]], [[4f9g]], [[6rm0]], [[6s86]] – hSTING C-di-GMP-binding domain + GMP derivative<br /> | ||
| - | **[[4f5d]] – hSTING C-di-GMP-binding domain (mutant) + GMP derivative <br /> | ||
| - | **[[6cff]], [[6cy7]] – hSTING C-di-GMP-binding domain + AMP derivative <br /> | ||
| - | **[[4ksy]], [[4loh]], [[5bqx]], [[6dnk]], [[6xnp]], [[6s26]], [[6s27]] – hSTING C-di-GMP-binding domain + GMP-AMP derivative <br /> | ||
| - | **[[4loi]], [[6mx3]], [[6mxe]] – hSTING C-di-GMP-binding domain (mutant) + GMP-AMP derivative <br /> | ||
| - | **[[6dxg]], [[6dxl]], [[6ukm]], [[6uku]], [[6ukv]], [[6ukw]], [[6ukx]], [[6uky]], [[6ukz]], [[6ul0]] – hSTING C-di-GMP-binding domain + agonist <br /> | ||
| - | **[[4qxo]] – hSTING C-di-GMP-binding domain + drug <br /> | ||
| - | **[[4qxp]], [[4qxq]], [[4qxr]] – hSTING C-di-GMP-binding domain (mutant) + drug <br /> | ||
| - | **[[5jej]] – hSTING PLPLRT/SD motif + IRF-3 CTD <br /> | ||
| - | **[[6o8b]], [[6o8c]] – hSTING PLPLRT/SD motif (mutant) + TBK1 <br /> | ||
| - | **[[6a03]], [[6a04]], [[6a05]], [[6a06]] – pSTING C-di-GMP-binding domain + ligand <br /> | ||
| - | **[[4kby]] – mSTING C-di-GMP-binding domain+ GMP derivative<br /> | ||
| - | **[[4loj]], [[4lok]], [[4yp1]] – mSTING C-di-GMP-binding domain + GMP-AMP derivative <br /> | ||
| - | **[[6xnn]] – mSTING C-di-GMP-binding domain + GMP-AMP derivative <br /> | ||
| - | **[[4lol]] – mSTING C-di-GMP-binding domain + drug <br /> | ||
| - | **[[4jc5]] – mSTING C-di-GMP-binding domain + immune activator <br /> | ||
| - | **[[5grm]] – rSTING C-di-GMP-binding domain + GMP-AMP derivative <br /> | ||
| - | **[[6nt7]], [[6nt8]] – cSTING + GMP-AMP derivative - Cryo EM<br /> | ||
| - | **[[6nt9]] – cSTING + TBK1 - Cryo EM<br /> | ||
| - | **[[5cfl]], [[5cfm]], [[5cfq]] – aSTING C-di-GMP-binding domain + GMP derivative <br /> | ||
| - | **[[5cfp]] – aSTING C-di-GMP-binding domain (mutant) + GMP derivative<br /> | ||
| - | **[[5cfn]] – aSTING C-di-GMP-binding domain + AMP derivative <br /> | ||
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| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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References
- ↑ Shang G, Zhang C, Chen ZJ, Bai XC, Zhang X. Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. Nature. 2019 Mar 6. pii: 10.1038/s41586-019-0998-5. doi:, 10.1038/s41586-019-0998-5. PMID:30842659 doi:http://dx.doi.org/10.1038/s41586-019-0998-5
- ↑ Zhao B, Du F, Xu P, Shu C, Sankaran B, Bell SL, Liu M, Lei Y, Gao X, Fu X, Zhu F, Liu Y, Laganowsky A, Zheng X, Ji JY, West AP, Watson RO, Li P. A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature. 2019 May;569(7758):718-722. doi: 10.1038/s41586-019-1228-x. Epub 2019 May, 22. PMID:31118511 doi:http://dx.doi.org/10.1038/s41586-019-1228-x
- ↑ Dobbs N, Burnaevskiy N, Chen D, Gonugunta VK, Alto NM, Yan N. STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease. Cell Host Microbe. 2015 Aug 12;18(2):157-68. doi: 10.1016/j.chom.2015.07.001., Epub 2015 Jul 30. PMID:26235147 doi:http://dx.doi.org/10.1016/j.chom.2015.07.001
- ↑ Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ. Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA. Cell. 2013 Aug 15;154(4):748-62. doi: 10.1016/j.cell.2013.07.023. Epub 2013 Aug, 1. PMID:23910378 doi:10.1016/j.cell.2013.07.023
