1edm

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Revision as of 14:35, 12 November 2007

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spinqualitylabelsall models 1edm, resolution 1.5Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

EPIDERMAL GROWTH FACTOR-LIKE DOMAIN FROM HUMAN FACTOR IX

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Various diverse extracellular proteins possess Ca(2+)-binding epidermal, growth factor (EGF)-like domains, the function of which remains uncertain., We have determined, at high resolution (1.5 A), the crystal structure of, such a domain, from human clotting factor IX, as a complex with Ca2+. The, Ca2+ ligands form a classic pentagonal bipyramid with six ligands, contributed by one polypeptide chain and the seventh supplied by a, neighboring EGF-like domain. The crystal structure identifies the role of, Ca2+ in maintaining the conformation of the N-terminal region of the, domain, but more importantly demonstrates that Ca2+ can directly mediate, protein-protein contacts. The observed crystal packing of the domains, provides a plausible model for the association of multiple tandemly linked, EGF-like domains in proteins such as fibrillin-1, Notch, and protein S., This model is consistent with the known functional data and suggests a, general biological role for these domains.

Disease

Known diseases associated with this structure: Hemophilia B OMIM:[306900], Warfarin sensitivity OMIM:[306900]

About this Structure

1EDM is a Single protein structure of sequence from Homo sapiens with CA as ligand. Full crystallographic information is available from OCA.

Reference

The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions., Rao Z, Handford P, Mayhew M, Knott V, Brownlee GG, Stuart D, Cell. 1995 Jul 14;82(1):131-41. PMID:7606779

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