This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1guk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1guk.gif|left|200px]]
[[Image:1guk.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1guk |SIZE=350|CAPTION= <scene name='initialview01'>1guk</scene>, resolution 2.9&Aring;
+
The line below this paragraph, containing "STRUCTURE_1guk", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1guk| PDB=1guk | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1guk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guk OCA], [http://www.ebi.ac.uk/pdbsum/1guk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1guk RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF MURINE ALPHA-CLASS GSTA4-4'''
'''CRYSTAL STRUCTURE OF MURINE ALPHA-CLASS GSTA4-4'''
Line 30: Line 27:
[[Category: Krengel, U.]]
[[Category: Krengel, U.]]
[[Category: Schroter, K H.]]
[[Category: Schroter, K H.]]
-
[[Category: crystal structure]]
+
[[Category: Crystal structure]]
-
[[Category: glutathione s-transferase]]
+
[[Category: Glutathione s-transferase]]
-
[[Category: gst]]
+
[[Category: Gst]]
-
[[Category: oxidative stress]]
+
[[Category: Oxidative stress]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:01:31 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:51:33 2008''
+

Revision as of 15:01, 2 May 2008

Image:1guk.gif

Template:STRUCTURE 1guk

CRYSTAL STRUCTURE OF MURINE ALPHA-CLASS GSTA4-4


Overview

Glutathione S-transferases (GSTs) are ubiquitous multifunctional enzymes which play a key role in cellular detoxification. The enzymes protect the cells against toxicants by conjugating them to glutathione. Recently, a novel subgroup of alpha-class GSTs has been identified with altered substrate specificity which is particularly important for cellular defense against oxidative stress. Here, we report the crystal structure of murine GSTA4-4, which is the first structure of a prototypical member of this subgroup. The structure was solved by molecular replacement and refined to 2.9 A resolution. It resembles the structure of other members of the GST superfamily, but reveals a distinct substrate binding site.

About this Structure

1GUK is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a murine alpha-class glutathione S-transferase involved in cellular defense against oxidative stress., Krengel U, Schroter KH, Hoier H, Arkema A, Kalk KH, Zimniak P, Dijkstra BW, FEBS Lett. 1998 Feb 6;422(3):285-90. PMID:9498801 Page seeded by OCA on Fri May 2 18:01:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1guk"
Personal tools