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1gvg

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[[Image:1gvg.jpg|left|200px]]
[[Image:1gvg.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1gvg |SIZE=350|CAPTION= <scene name='initialview01'>1gvg</scene>, resolution 1.54&Aring;
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The line below this paragraph, containing "STRUCTURE_1gvg", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Nmo+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AKG:2-OXYGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NO:NITROGEN+OXIDE'>NO</scene>, <scene name='pdbligand=PCX:DEOXYGUANIDINOPROCLAVAMINIC+ACID'>PCX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1gvg| PDB=1gvg | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvg OCA], [http://www.ebi.ac.uk/pdbsum/1gvg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gvg RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF CLAVAMINATE SYNTHASE WITH NITRIC OXIDE'''
'''CRYSTAL STRUCTURE OF CLAVAMINATE SYNTHASE WITH NITRIC OXIDE'''
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[[Category: Schofield, C J.]]
[[Category: Schofield, C J.]]
[[Category: Zhang, Z H.]]
[[Category: Zhang, Z H.]]
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[[Category: clavaminate synthase 1]]
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[[Category: Clavaminate synthase 1]]
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[[Category: jelly roll]]
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[[Category: Jelly roll]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: nitric oxide]]
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[[Category: Nitric oxide]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: oxygenase]]
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[[Category: Oxygenase]]
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[[Category: trifunctional enzyme]]
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[[Category: Trifunctional enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:03:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:52:06 2008''
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Revision as of 15:03, 2 May 2008

Image:1gvg.jpg

Template:STRUCTURE 1gvg

CRYSTAL STRUCTURE OF CLAVAMINATE SYNTHASE WITH NITRIC OXIDE


Overview

Clavaminate synthase (CAS), a 2-oxoglutarate (2OG) dependent dioxygenase, catalyses three steps in the biosynthesis of clavulanic acid. Crystals of CAS complexed with Fe(II), 2OG and deoxyguanidinoproclavaminate were exposed to nitric oxide (NO) acting as a dioxygen analogue. Prior to exposure with NO, the active site Fe(II) is octahedrally coordinated by a water molecule, the 2-oxo and 1-carboxylate groups of 2OG, and the side-chains of an aspartyl and two histidinyl residues. NO binds to the position previously occupied by the 2OG 1-carboxylate concomitant with rearrangement of the latter to the position previously occupied by the displaced water.

About this Structure

1GVG is a Single protein structure of sequence from Streptomyces clavuligerus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements., Zhang Z, Ren J, Harlos K, McKinnon CH, Clifton IJ, Schofield CJ, FEBS Lett. 2002 Apr 24;517(1-3):7-12. PMID:12062399 Page seeded by OCA on Fri May 2 18:03:35 2008

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