1gvn

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[[Image:1gvn.jpg|left|200px]]
[[Image:1gvn.jpg|left|200px]]
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{{Structure
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|PDB= 1gvn |SIZE=350|CAPTION= <scene name='initialview01'>1gvn</scene>, resolution 1.95&Aring;
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The line below this paragraph, containing "STRUCTURE_1gvn", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=SOB:So4+Binding+Site+For+Chain+D'>SOB</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_1gvn| PDB=1gvn | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvn OCA], [http://www.ebi.ac.uk/pdbsum/1gvn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gvn RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE PLASMID MAINTENANCE SYSTEM EPSILON/ZETA: MEACHNISM OF TOXIN INACTIVATION AND TOXIN FUNCTION'''
'''CRYSTAL STRUCTURE OF THE PLASMID MAINTENANCE SYSTEM EPSILON/ZETA: MEACHNISM OF TOXIN INACTIVATION AND TOXIN FUNCTION'''
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[[Category: Saenger, W.]]
[[Category: Saenger, W.]]
[[Category: Straeter, N.]]
[[Category: Straeter, N.]]
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[[Category: plasmid]]
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[[Category: Plasmid]]
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[[Category: postsegregational killing system]]
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[[Category: Postsegregational killing system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:04:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:52:13 2008''
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Revision as of 15:04, 2 May 2008

Image:1gvn.jpg

Template:STRUCTURE 1gvn

CRYSTAL STRUCTURE OF THE PLASMID MAINTENANCE SYSTEM EPSILON/ZETA: MEACHNISM OF TOXIN INACTIVATION AND TOXIN FUNCTION


Overview

Programmed cell death in prokaryotes is frequently found as postsegregational killing. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid. The broad-host-range, low-copy-number plasmid pSM19035 from Streptococcus pyogenes carries the genes encoding the antitoxin/toxin system epsilon/zeta and antibiotic resistance proteins, among others. The crystal structure of the biologically nontoxic epsilon(2)zeta(2) protein complex at a 1.95-A resolution and site-directed mutagenesis showed that free zeta acts as phosphotransferase by using ATPGTP. In epsilon(2)zeta(2), the toxin zeta is inactivated because the N-terminal helix of the antitoxin epsilon blocks the ATPGTP-binding site. To our knowledge, this is the first prokaryotic postsegregational killing system that has been entirely structurally characterized.

About this Structure

1GVN is a Protein complex structure of sequences from Streptococcus pyogenes. Full crystallographic information is available from OCA.

Reference

Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation., Meinhart A, Alonso JC, Strater N, Saenger W, Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1661-6. Epub 2003 Feb 5. PMID:12571357 Page seeded by OCA on Fri May 2 18:04:00 2008

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